For our SNPs discovered in resequencing, especially non-synonymous SNPs and for SNPs identified or predicted computationally.  Assays for the SNPs have been developed with Sequenom and the entire Reynold's population is inspected for each of those SNPs.

Association Study Data (March 2003)

Dallas Heart Disease Prevention Program Population

Donald W. Reynolds Cardiovascular Clinical Research Center

A random, multiethnic population data base will be developed by testing of 7000 individuals aged 18-65 from Dallas County. Subjects will be characterized with respect to medical history, family history, blood pressure, fasting lipoproteins and other plasma constituents, EKG, MRI to assess cardiac mass and geometry, MRI to assess regional body fat, and EBCT to assess coronary calcification. DNA will be banked from each subject for genotyping. Subjects will be followed by telephone contact, and by automated tracking of hospital admissions to 47 area hospitals.

Selected individuals from this population who manifest specific phenotypes will participate in one or more substudies that are funded by the original grant, and that call for additional detailed testing, in some cases including admission to the General Clinical Research Center (GCRC). Importantly, this population data base is intended also to serve as a resource for additional studies to be proposed subsequently, and funded from other sources. We will welcome proposals from other investigators, from UTSWMC or elsewhere, for additional analyses using this population.